Chapter 11: Problem 28
What is a glycoside bond? How is it formed?
Short Answer
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Answer: A glycoside bond is a covalent bond that connects a carbohydrate molecule to another molecule, such as another carbohydrate or a non-carbohydrate molecule like an alcohol or an amine. It is formed through a condensation reaction, also known as a dehydration reaction, involving the following steps: 1) Protonation of the anomeric carbon of the carbohydrate, 2) nucleophilic attack by the hydroxyl group or another nucleophile of the second molecule, and 3) deprotonation with the elimination of a water molecule, resulting in the glycoside bond.
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