Problem 6
Give the sequence on the opposite strand for ACGTAT, AGATCT, and ATGGTA (all read \(5^{\prime} \rightarrow 3^{\prime}\) ).
Problem 8
(a) Is it biologically advantageous that DNA is stable? Why or why not? (b) Is it biologically advantageous that RNA is unstable? Why or why not?
Problem 9
A friend tells you that only four different kinds of bases are found in RNA. What would you say in reply?
Problem 10
In the early days of molecular biology, some researchers speculated that RNA, but not DNA, might have a branched rather than linear covalent structure. Why might this speculation have come about?
Problem 11
Why is RNA more vulnerable to alkaline hydrolysis than DNA?
Problem 14
Which of the following statements is (are) true? (a) Bacterial ribosomes consist of \(40 \mathrm{S}\) and \(60 \mathrm{S}\) subunits. (b) Prokaryotic DNA is normally complexed with histones. (c) Prokaryotic DNA normally exists as a closed circle. (d) Circular DNA is supercoiled.
Problem 15
What are the two principal opposing views regarding the patenting of genes?
Problem 18
How do the major and minor grooves in B-DNA compare to those in A-DNA?
Problem 19
Which of the following statements is (are) true? (a) The two strands of DNA run parallel from their 5 ' to their 3 ' ends. (b) An adenine-thymine base pair contains three hydrogen bonds. (c) Positively charged counterions are associated with DNA. (d) DNA base pairs are always perpendicular to the helix axis.
Problem 20
Define supercoiling, positive supercoil, topoisomerase, and negative supercoil.
