Problem 34
In what sense is mitochondrial ATP synthase a motor protein?
Problem 35
What is the approximate \(P / O\) ratio that can be expected if intact mitochondria are incubated in the presence of oxygen, along with added succinate?
Problem 37
What are some of the difficulties in determining the exact number of protons pumped across the inner mitochondrial membrane by the respiratory complexes?
Problem 38
Briefly summarize the main arguments of the chemiosmotic coupling hypothesis.
Problem 40
Briefly describe the role of uncouplers in oxidative phosphorylation.
Problem 41
What role does the proton gradient play in chemiosmotic coupling?
Problem 44
Can an uncoupler of oxidative phosphorylation inhibit electron transport from one component of the electron transport chain to another? Why or why not?
Problem 47
How does the yield of ATP from complete oxidation of one molecule of glucose in muscle and brain differ from that in liver, heart, and kidney? What is the underlying reason for this difference?
