Question

Oligodendrocytes progenitors are identified by A2B5 antibody whereas pre- oligodendrocytes are identified by \(O 4\) antibody. a. True b. False

Short answer

Answer: True

Step-by-step solution

Understanding the terms and statement

First, let's understand the terms oligodendrocytes progenitors and pre-oligodendrocytes. Oligodendrocytes are a type of glial cell in the central nervous system (CNS) that produce myelin, which insulates and protects neurons. Oligodendrocyte progenitors (OPCs) are precursor cells that develop into oligodendrocytes. Pre-oligodendrocytes are a stage between OPCs and mature oligodendrocytes, they are immature oligodendrocytes that have not yet started producing myelin. The given statement says that the A2B5 antibody identifies OPCs, while the O4 antibody identifies pre-oligodendrocytes.

Research about antibodies and cell markers

After researching in the scientific literature, we find that the A2B5 antibody is indeed a commonly used marker to identify OPCs. Similarly, the O4 antibody is a well-known marker for pre-oligodendrocytes and immature oligodendrocytes.

Concluding the answer

Based on the information obtained from the research, the given statement in the exercise is correct. The A2B5 antibody is used to identify OPCs, and the O4 antibody is used to identify pre-oligodendrocytes. Therefore, the correct answer is: a. True