Question

MR spectroscopy does not: a. demonstrate increased myo-inositol in high grade astrocytomas. b. potentially only demonstrates subtle findings for gliomatosis cerebri. c. demonstrate increased myo-inositol in low grade astrocytomas. d. show glutamate and glutamine elevations in low-grade oligodendrogliomas.

Short answer

a) demonstrate increased myo-inositol in high grade astrocytomas b) potentially only demonstrates subtle findings for gliomatosis cerebri c) demonstrate increased myo-inositol in low grade astrocytomas d) show glutamate and glutamine elevations in low-grade oligodendrogliomas Answer: a) demonstrate increased myo-inositol in high grade astrocytomas

Step-by-step solution

Understand MR spectroscopy and its uses

MR spectroscopy is a noninvasive imaging technique that provides metabolic information on tumors and other lesions. It allows for the detection of certain metabolites within the tissues, helping clinicians with diagnosis, treatment planning, and monitoring treatment response.

Analyze statement a

Statement a - "demonstrate increased myo-inositol in high grade astrocytomas": This statement implies that MR spectroscopy can detect an increase in the myo-inositol level in high-grade astrocytomas. Myo-inositol is a marker often associated with low-grade gliomas, so this statement might not be true.

Analyze statement b

Statement b - "potentially only demonstrates subtle findings for gliomatosis cerebri": Gliomatosis cerebri is a rare and diffusely infiltrative brain tumor. MR spectroscopy can sometimes show subtle metabolic changes in this type of tumor, which might not be easily identified on conventional MR imaging. This statement could be accurate.

Analyze statement c

Statement c - "demonstrate increased myo-inositol in low grade astrocytomas": This statement implies that MR spectroscopy can detect an increase in the myo-inositol level in low-grade astrocytomas. As mentioned before, myo-inositol is commonly associated with low-grade gliomas, making this statement true.

Analyze statement d

Statement d - "show glutamate and glutamine elevations in low-grade oligodendrogliomas": Glutamate and glutamine are amino acids that can be elevated in low-grade oligodendrogliomas. MR spectroscopy can identify these elevations in such cases, which can assist in tumor characterization. This statement is accurate.

Identify the false statement

Now that we have analyzed each statement, we can determine that statement a - "demonstrate increased myo-inositol in high grade astrocytomas" is not true. This is because myo-inositol is typically associated with low-grade gliomas rather than high-grade astrocytomas.