Question

Immune synapses in the CNS are MHC-II-expressing microglia interacting with T-helper lymphocytes. True/False

Short answer

Answer: True

Step-by-step solution

Understanding Immune Synapses

Immune synapses are specialized cell-cell junctions between immune cells, facilitating signal transduction and communication. They play a crucial role in the immune response.

Understanding Microglia and their role

Microglia are immune cells in the CNS that act as the primary form of active immune defense, protecting the nervous system. They can express MHC-II molecules on their surface and present antigens to T-helper lymphocytes to trigger an immune response.

Understanding T-helper lymphocytes and their role

T-helper lymphocytes (also called CD4+ T cells) are a type of white blood cell that helps coordinate the immune response. They recognize antigens presented by APC (Antigen Presenting Cells) and activate other immune cells such as cytotoxic T cells and B cells to help fight infection.

CNS, Microglia, and T-helper lymphocytes interaction

Immune synapses in the CNS involve interactions between MHC-II-expressing microglia and T-helper lymphocytes. The microglia present antigens through their MHC-II molecules, and the T-helper lymphocytes recognize and respond accordingly. This interaction is crucial for regulating immune responses within the CNS.

Determine if the statement is True or False

Based on the understanding of immune synapses, microglia, and T-helper lymphocytes, we can conclude that the statement is True. Immune synapses in the CNS are indeed MHC-II-expressing microglia interacting with T-helper lymphocytes.