Question

Causative mutations in which of the following genes has been described in early-onset \(\mathrm{AD}\) ? a. amyloid precursor protein, presenilin-1, presenilin- 2 b. presenilin-1, amyloid precursor protein, apolipoprotein \(\mathrm{C}\) c. presenilin-1, presenilin-2, apolipoprotein \(C\) d. apolipoprotein C, presenilin-2, amyloid precursor protein e. huntingtin, presenilin-1, presenilin-2

Short answer

Answer: The causative mutations for early-onset Alzheimer's Disease are found in the amyloid precursor protein (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2) genes.

Step-by-step solution

Recall early-onset AD genes

Recall that the primary genes associated with early-onset AD are amyloid precursor protein (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2).

Compare options with genes

Compare the options provided in the exercise with the known genes for early-onset AD: a. amyloid precursor protein, presenilin-1, presenilin- 2 b. presenilin-1, amyloid precursor protein, apolipoprotein C c. presenilin-1, presenilin-2, apolipoprotein C d. apolipoprotein C, presenilin-2, amyloid precursor protein e. huntingtin, presenilin-1, presenilin- 2

Choose the correct option

Based on the information above, choose the correct option which represents the causative mutations in the genes for early-onset AD. In this case, it is option a. amyloid precursor protein, presenilin-1, presenilin- 2.