Question

What is a primary neurogenic region and target site of the adult brain a. the subventricular zone to the olfactory bulb b. the subventricular zone to the rostral migratory stream c. the subgranular zone to the rostral migratory stream d. the subgranular zone to the pyramidal cell layer of the hippocampus.

Short answer

Answer: The subventricular zone to the olfactory bulb.

Step-by-step solution

Primary neurogenic regions

Primary neurogenic regions are specific areas in the adult brain where the generation of new neurons takes place. There are two main primary neurogenic regions in the adult mammalian brain: the subventricular zone (SVZ) and the subgranular zone (SGZ). Step 2: Identifying the target sites

Target sites

The target sites refer to the destinations where the newly generated neurons migrate to and differentiate into mature neurons. The olfactory bulb is the target site for neurogenesis in the subventricular zone (SVZ), while the dentate gyrus within the hippocampus is the target site for neurogenesis in the subgranular zone (SGZ). Step 3: Complex migration route - rostral migratory stream

Rostral migratory stream (RMS)

The rostral migratory stream (RMS) is the complex and well-defined migration route through which newly generated neurons from the subventricular zone (SVZ) migrate towards the olfactory bulb. Step 4: Matching the primary neurogenic regions with target sites

Matching neurogenic regions and target sites

Now we combine our findings from Steps 1 to 3 to determine the correct answer: - The subventricular zone (SVZ) gives rise to new neurons that migrate towards the olfactory bulb via the rostral migratory stream (RMS). - The subgranular zone (SGZ) gives rise to new neurons that migrate to the pyramidal cell layer of the hippocampus. Step 5: Identifying the correct answer

Correct answer

By matching the primary neurogenic regions and target sites from Step 4, the correct answer is: a. the subventricular zone to the olfactory bulb