Chapter 27: Problem 14
Studies of which disease have provided an increased understanding of the interactions between neurology and immunology? a. Mollaret's Meningitis b. Guillan Barre Syndrome c. poliomyelitis d. multiple sclerosis
Chapter 27: Problem 14
Studies of which disease have provided an increased understanding of the interactions between neurology and immunology? a. Mollaret's Meningitis b. Guillan Barre Syndrome c. poliomyelitis d. multiple sclerosis
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Get started for freeProstaglandins have a dual role in either promoting neuronal survival or apoptotic death. What factors may determine which role predominates in CNS injury or degeneration? 1\. Target cell and tissue environment, degree of cellular response to the inflammatory mediators, and profile of specific prostaglandin(s) 2\. Exposure to prostaglandin and cox-2 inhibitors, target cell and tissue environment, and profile of specific prostaglandins(s) a. both 1 and 2 b. neither 1 or 2 c. 1 d. 2
Which of the following proposed pathogenic mechanisms in ALS are considered mutually exclusive (present in isolation) of other proposed mechanisms of disease? a. glutamate excitotoxicity b. generation of free radicals c. disrupted axoplasmic flow d. altered calcium homeostasis e. all of the above f. none of the above
Which line(s) of evidence from animal and in vitro studies support that the immune inflammatory response has a role in motoneuron injury? a. Studies from mSOD transgenic chimeric mice showing that mSOD expressing neurons that are surrounded by wild-type glial cells remain intact b. Motoneuron injury by activated microglia mediated by glutamate and peroxynitrite c. Both \(a\) and \(b\) d. Neither a or b
Which statement best describes the meaning of 'non-cell autonomy' when referring to the pathogenesis of ALS? a. The risk of developing ALS is independent of cellular factors, and is more dependent on environmental exposures. b. The progression of disease in ALS is dependent upon therapeutic intervention and early detection c. Motor neuron injury is independent of interaction with other cell populations within the CNS d. Motor neuron injury is dependent on interaction with other affected cell populations within the CNS
Which line(s) of evidence from human studies support that the immune inflammatory response in \(\mathrm{ALS}\) has a role in amplifying disease progression? a. Increased expression of myeloid dendritic cells mRNA transcripts in ALS spinal cord that correlates with a faster rate of progression b. Increased mRNA expressions of the chemokine MCP-1, and the cytokine macrophage-colony stimulating factor (M-CSF) in ALS spinal cord, which attracts and induces differentiation of monocytes and myeloid dendritic cells, respectively. c. Both a and b d. Neither a or b
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