Chapter 27: Problem 12
Cognitive dysfunction is not a typical feature of ALS. True/False
Chapter 27: Problem 12
Cognitive dysfunction is not a typical feature of ALS. True/False
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Get started for freeWhich line(s) of evidence from animal and in vitro studies support that the immune inflammatory response has a role in motoneuron injury? a. Studies from mSOD transgenic chimeric mice showing that mSOD expressing neurons that are surrounded by wild-type glial cells remain intact b. Motoneuron injury by activated microglia mediated by glutamate and peroxynitrite c. Both \(a\) and \(b\) d. Neither a or b
Association between viral infection and motor neuron disease is based upon cases of motor neuron disease due to retroviral infection (HIV, HTLV-1) and the presence of serum antibodies directed toward endogenous retroviral gene sequences in ALS patients. True/False
Which line(s) of evidence from human studies support that the immune inflammatory response in \(\mathrm{ALS}\) has a role in amplifying disease progression? a. Increased expression of myeloid dendritic cells mRNA transcripts in ALS spinal cord that correlates with a faster rate of progression b. Increased mRNA expressions of the chemokine MCP-1, and the cytokine macrophage-colony stimulating factor (M-CSF) in ALS spinal cord, which attracts and induces differentiation of monocytes and myeloid dendritic cells, respectively. c. Both a and b d. Neither a or b
In vitro, motor neuron injury is induced by exposure to activated microglia. Which microglial constituents initiate such injury? 1\. kainite and \(\mathrm{IgG}\) 2\. mSOD1 and peroxynitrite 3\. glutamate and \(I g G\) 4\. peroxynitrite and glutamate a. \(1,2,3\) b. 1,3 c. 2,4 d. 4 only
In CNS injury, the neuroprotective response of activated T cells is dependent upon early activation and differentiation of microglia into antigen presenting cells which release neurotrophic growth factors. True/False
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