Chapter 18: Problem 15
Optic neuritis is the presenting symptom in what percentage of MS patients? a. \(10 \%\) b. \(20 \%\) c. \(30 \%\) d. \(40 \%\) e. \(50 \%\)
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In the pathogenesis of MS, molecular mimicry implies: a. Recepooes mediating T-cell migration have overlapping function, i.e, they can mimic each other's ligand specificity. b. Immune modulating chemokines or cytokines can mimic the molecular functions of each other. c. Structural similarity of foreign antigens and myelin protein components may lead to cross-recognition by myelin-reactive T-cells. d. Suppression of selected T-cell responses can have a global impact on both CD4+ and CD8+ T-cells. 10\. Comparison of EAE with MS shows the following:
In the pathogenesis of \(\mathrm{MS}\), molecular mimicry implies: a. Receptors mediating T-cell migration have overlapping function, i.e., they can mimic each other's ligand specificity. b. Immune modulating chemokines or cytokines can mimic the molecular functions of each other. c. Structural similarity of foreign antigens and myelin protein components may lead to cross-recognition by myelin-reactive T-cells. d. Suppression of selected T-cell responses can have a global impact on both CD4+ and CD8+ T-cells.
Which immunomodulatory therapies are frequently used in MS? a. IFN- \(\beta\) b. IFN-y c. Copolymer-1 d. corticosteroids e. all of the above f. \(a, b\) \& d
Apoptosis of which cell type is a histological hallmark of at least one pathologic subtype of MS plaque? a. neuron b. astrocyte c. oligodendrocyte d. macrophage e. none of the above
MS plaques have been histologically demonstrated to include: a. infiltration of CD8+ T-cells b. infiltration of CD4+ T-cells c. infiltration of B-cells d. \(\mathrm{IgG}\) deposition e. Complement deposition f. all of the above g. \(a\) \& b h. \(a, b\) \& c i. \(a, b, c \& d\)
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