Question

The chemokine co-receptors for HIV-infection infection are? a. CXCR7 and CCR1 b. CCR1 and \(\mathrm{CCR} 5\) c. CXCR4 and CCR1

Short answer

Answer: CCR1 and CCR5

Step-by-step solution

Understand chemokine co-receptors and their role in HIV infection

Chemokine co-receptors are proteins present on the surface of immune cells, like T-cells. They play a crucial role in the infection process of HIV. The virus binds to the main receptor (CD4) and a co-receptor to enter the target cells. Two major co-receptors for HIV infection are CCR5 and CXCR4.

Evaluate each given pair of chemokine co-receptors

Now let's evaluate each of the given pairs in the answer choices: a. CXCR7 and CCR1: CXCR7 is not known to be involved in HIV infection and CCR1 has a minor role in it. b. CCR1 and CCR5: Though CCR1 has a minor role in HIV infection, this option includes CCR5 which is one of the major co-receptors. c. CXCR4 and CCR1: This option includes CXCR4, which is a major co-receptor, but CCR1 has a minor role in HIV infection.

Choose the correct answer

Based on the evaluation of the given options, it is evident that none of the options include both major co-receptors (CCR5 and CXCR4); however, option (b) CCR1 and CCR5, comes the closest as it includes CCR5, which is one of the major co-receptors for HIV infection. Even though CCR1 has a minor role, this option is still the best choice among the given answers.