Question

Which receptor does SDF-1 activate to induce migration of NPC? a. \(\mathrm{CCR} 2\) b. \(\mathrm{CCR} 4\) c. CXCR4 d. CX3CRl

Short answer

Answer: c. CXCR4

Step-by-step solution

Understand SDF-1 and NPC

SDF-1, also known as Stromal cell-derived factor 1 or CXCL12, is a chemokine molecule that plays a role in various biological processes, including cell migration and immune responses. NPC stands for Neural Progenitor Cells, which are precursor cells that can develop into different types of neurons and glial cells.

Identify the receptor activated by SDF-1

The receptor activated by SDF-1 to induce migration of NPC is known as CXCR4. CXCR4 is a G-protein-coupled receptor that plays a role in various cellular processes, including cell migration and immune responses.

Choose the correct answer among the options

The correct answer is the one that corresponds to CXCR4. In the given options: a. CCR2 b. CCR4 c. CXCR4 d. CX3CR1 The correct answer is option c, which is CXCR4.