Question

Which of the following proteins is a major constituent of synaptic ribbons? a. Retinol dehydrogenase b. Melanin c. Ribeye d. RGS/G \(\beta 5\) e. Bestrophin

Short answer

Answer: Ribeye

Step-by-step solution

Understand synaptic ribbons

Synaptic ribbons are electron-dense structures found at the active zones of certain synapses, particularly in sensory neurons, such as photoreceptors and hair cells. These structures play an important role in the release of neurotransmitters to facilitate communication between neurons.

Review the list of proteins

The given list of proteins includes: a. Retinol dehydrogenase b. Melanin c. Ribeye d. RGS/Gß5 e. Bestrophin

Eliminate irrelevant proteins

a. Retinol dehydrogenase: an enzyme involved in the metabolism of retinoids, not related to synaptic ribbons. b. Melanin: a pigment responsible for skin and hair color, not related to synaptic ribbons. d. RGS/Gß5: a complex that regulates G protein signaling, not directly related to synaptic ribbons. e. Bestrophin: a calcium-activated chloride channel protein, not directly related to synaptic ribbons.

Identify the correct protein

c. Ribeye: Ribeye is a major protein component of synaptic ribbons. It is essential for the formation and function of these structures and is found at the core of synaptic ribbons.

Conclusion

The major constituent of synaptic ribbons is Ribeye (c).