Matching:
Match the antihypertensive class with the mechanism.
Antihypertensive class Mechanism by which it decreases blood pressure
1\. Diuretics A. Decreases sympathetic stimulation from the central nervous
system, resulting in decreased heart rate, decreased vasoconstriction, and
decreased vascular resistance within the kidneys.
2\. Beta blockers B. Cause vasodilation by blocking the receptor sites of
alpha-1
adrenergic receptors.
3\. Calcium channel blockers C. Blocks the receptor sites of angiotensin II,
thus preventing the
vasoconstricting eff ects. Prevents the release of aldosterone,
which causes increased sodium and water reabsorption.
4\. Angiotensin-converting enzyme
inhibitors (ACE inhibitors)
D. Decreases heart rate, resulting in decreased cardiac output.
5\. Angiotensin II receptor antagonists E. Causes direct relaxation to
arterioles, resulting in decreased
peripheral resistance.
6\. Centrally acting alpha-2
stimulators
F. Inhibits the conversion of angiotensin I to angiotensin II,
thereby preventing the vasoconstrictive actions of angiotensin II.
Prevents the release of aldosterone, which causes increased
sodium and water reabsorption.
7\. Peripherally acting alpha-1
blockers
G. Decreases reabsorption of water in the kidneys, resulting in decreased
circulating volume and decreased peripheral resistance.
8\. Alpha-1 beta blockers H. Decreases heart rate, resulting in decreased
cardiac output, and
causes dilation of peripheral vessels resulting in decreased vascular
resistance.
9\. Direct vasodilators I. Decreases the mechanical contraction of the heart
by inhibiting
the movement of calcium across cell membranes. Also dilates
coronary vessels and peripheral arteries.