Diabetes Insipidus is a medical condition where the kidneys are unable to conserve water, leading to the release of large amounts of dilute urine. This disease is distinct from diabetes mellitus, which involves blood sugar regulation. In diabetes insipidus, the underlying issue is related to the hormone vasopressin, also known as antidiuretic hormone (ADH). Vasopressin is responsible for signaling the kidneys to retain water in the body. When there is a deficiency of vasopressin or a failure in response to it, the kidneys release excess water, causing frequent urination.
There are two main types of diabetes insipidus:
- Central Diabetes Insipidus: This results from the pituitary gland not producing enough vasopressin.
- Nephrogenic Diabetes Insipidus: In this type, the kidneys do not respond to vasopressin properly, often due to a genetic condition or complications from certain medications.
Symptoms include excessive thirst, dehydration, and the need to urinate often and in large volumes. Diagnosing includes urine tests to assess concentration levels and blood tests to examine electrolyte imbalances.