Question

A client with end stage renal failure has received a renal transplant. Which statement describes hyperacute graft rejection in the client with a renal transplant? A. Hyperacute graft rejection is due to chronic inflammation and scaring. B. Hyperacute graft rejection is a cellular response that occurs 1-3 weeks after transplantation. C. Hyperacute graft rejection is more likely in clients who have received multiple blood transfusions. D. Hyperacute graft rejection is managed by use of immunosuppressive medications.

Short answer

Answer: Hyperacute graft rejection is more likely in clients who have received multiple blood transfusions.

Step-by-step solution

Identify the subject

The subject is hyperacute graft rejection in the context of a renal transplant.

Evaluate each given statement

We will now go through each statement and determine whether it is a correct description of hyperacute graft rejection. A. Hyperacute graft rejection is due to chronic inflammation and scaring. - Incorrect: Hyperacute graft rejection is not due to chronic inflammation and scaring. It occurs within hours to days after the transplant and is caused by pre-existing antibodies. B. Hyperacute graft rejection is a cellular response that occurs 1-3 weeks after transplantation. - Incorrect: Hyperacute graft rejection is an antibody-mediated response that occurs immediately following the transplant. This timeframe is not consistent with hyperacute rejection. C. Hyperacute graft rejection is more likely in clients who have received multiple blood transfusions. - Correct: The presence of donor-specific anti-HLA antibodies from previous blood transfusions increases the risk of hyperacute graft rejection. The antibodies react immediately with the transplanted organ, causing rapid and severe rejection. D. Hyperacute graft rejection is managed by use of immunosuppressive medications. - Incorrect: Hyperacute graft rejection is not manageable with immunosuppressive medications. It usually requires immediate removal of the transplanted organ.

Choose the correct statement

From our evaluation, the correct statement is: C. Hyperacute graft rejection is more likely in clients who have received multiple blood transfusions.