Problem 1
Most DNA viruses replicate within nuclei of host cells, using host enzymes to replicate their DNA. In contrast, poxviruses replicate in the cytoplasm. What problem does this create for poxvirus replication? How could the virus overcome this problem?
Problem 4
A 10-year-old girl at summer camp complains of fever, runny nose, cough, sore throat, and tiredness. Within several hours, 36 other girls report to the infirmary with the same signs and symptoms. Although the girls were assigned to several different cabins and ate in two different dining halls, all of them had participated in outdoor archery, had gone horseback riding, and had been swimming in the camp pool. Infection with what DNA virus could account for their symptoms? The facts point to a common source of infection; what is it? What could the camp management do to limit such an outbreak in the future?
Problem 6
The World Health Organization (WHO), the United States, and Russia have repeatedly discussed the destruction of the two countries’ stocks of the smallpox virus, but deadlines for destruction have been postponed numerous times. In the meantime, the entire genome of variola major has been sequenced. What reasons can governments cite for maintaining smallpox viruses? Should all laboratory stores of smallpox viruses be destroyed? Given that the genome of the virus has been sequenced and that DNA can be synthesized, would elimination of all laboratory stocks really be the extinction of the smallpox virus?
Problem 7
After a patient complains that his eyes are extremely sensitive to light and feel gritty, his doctor informs him that he has ocular herpes. What causes ocular herpes? Which human herpesvirus, type 1 or type 2, is more likely to cause ocular herpes? Why?
