Problem 3
What similar problems are encountered with antiviral, antifungal, antiprotozoan, and antihelminthic drugs?
Problem 5
List the advantages of using two chemotherapeutic agents simultaneously to treat a disease. What problem can occur when two drugs are used?
Problem 6
Why does a cell die from the following antimicrobial actions? a. Colistimethate binds to phospholipids. b. Kanamycin binds to \(70 \mathrm{~S}\) ribosomes.
Problem 7
How does each of the following inhibit translation? a. chloramphenicol d. streptomycin b. erythromycin e. oxazolidinone c. tetracycline f. streptogramin
Problem 8
Dideoxyinosine (ddI) is an antimetabolite of guanine. The -OH is missing from carbon \(3^{\prime}\) in ddI. How does ddI inhibit DNA synthesis?
Problem 9
Compare the method of action of the following pairs: a. penicillin and echinocandin b. imidazole and polymyxin B
