Problem 1
Compare pathogenicity with virulence.
Problem 2
How are capsules and cell wall components related to pathogenicity? Give specific examples.
Problem 3
Describe how hemolysins, leukocidins, coagulase, kinases, hyaluronidase, siderophores, and IgA proteases might contribute to pathogenicity.
Problem 4
Explain how drugs that bind each of the following would affect pathogenicity: a. iron in the host's blood b. Neisseria gonorrhoeae fimbriae c. Streptococcus pyogenes \(\mathrm{M}\) protein
Problem 5
Compare and contrast the following aspects of endotoxins and exotoxins: bacterial source, chemistry, toxigenicity, and pharmacology. Give an example of each toxin.
Problem 7
Describe the factors contributing to the pathogenicity of fungi, protozoa, and helminths.
Problem 8
Which of the following genera is the most infectious? $$ \begin{array}{lllr} \text { Genus } & \text { ID }_{50} & \text { Genus } & \text { ID }_{50} \\ \hline \text { Legionella } & 1 \text { cell } & \text { Shigella } & 200 \text { cells } \\ \text { Salmonella } & 10^{5} \text { cells } & \text { Treponema } & 52 \text { cells } \end{array} $$
