Chapter 9: Problem 18
What structural feature allows DNA to store information?
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If one DNA strand is \(5^{\prime}\)-GGCATTACACTAGGCCT-3', what is the sequence of the complementary strand?
Look up the meaning of the word transformation in a dictionary and explain whether it is an appropriate word to describe the transfer of genetic material from one organism to another.
What part(s) of a nucleotide (namely, phosphate, sugar, and/or base) is(are) found in the major and minor grooves of doublestranded DNA, and what part(s) is(are) found in the DNA backbone? If a DNA-binding protein does not recognize a specific nucleotide sequence, do you expect that it binds to the major groove, the minor groove, or the DNA backbone? Explain.
In what ways are the structures of an \(\alpha\) helix in a protein and the double helix of DNA similar, and in what ways are they different?
A DNA-binding protein recognizes the following double-stranded sequence: $$ \begin{aligned} &5^{\prime}-\mathrm{GCCCGGGC}-3^{\prime} \\ &3^{\prime}-\mathrm{CGGGCCCG}-5^{\prime} \end{aligned} $$ This type of double-stranded structure could also occur within the stem region of an RNA stem-loop. Discuss the structural differences between RNA and DNA that might prevent the DNAbinding protein from recognizing a double-stranded RNA molecule.
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