Chapter 25: Problem 7
Discuss why a genetic disease might have a particular age of onset. Would an infectious disease have an age of onset? Explain why or why not.
Chapter 25: Problem 7
Discuss why a genetic disease might have a particular age of onset. Would an infectious disease have an age of onset? Explain why or why not.
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Get started for freeWhat is a prion? Explain how a prion relies on normal cellular proteins to cause a disease such as mad cow disease.
Achondroplasia is a rare form of dwarfism caused by an autosomal dominant mutation that affects the gene that encodes a fibroblast growth factor receptor. Among 1,422,000 live births, the number of babies born with achondroplasia was 31. Among those 31 babies, 18 of them had one parent with achondroplasia. The remaining babies had two unaffected parents. How do you explain those 13 babies, assuming that the mutant allele has \(100 \%\) penetrance? What are the odds that these 13 individuals will pass this mutant gene to their offspring?
Relatively few inherited forms of cancer involve the inheritance of mutant oncogenes. Instead, most inherited forms of cancer are defects in tumor- suppressor genes. Give two or more reasons why inherited forms of cancer seldom involve activated oncogenes.
Explain, at the molecular level, why human genetic diseases often follow a simple Mendelian pattern of inheritance, whereas most normal traits, such as the shape of your nose or the size of your head, are governed by multiple gene interactions.
With regard to pedigree analysis, make a list of observations that distinguish recessive, dominant, and \(\mathrm{X}\)-linked patterns of inheritance.
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