Question

TFIIB appears to interact with proteins that bind to sequences at the$3^{\text{'}}$end of genes. Explain how this interaction could enhance the transcription of a gene.

Short answer

TFIIB can connect to DNA directly at the promoter and indirectly at the gene's terminus, forming a DNA loop that will quickly start the transcription.

Step-by-step solution

Definition of TFIIB

RNA polymerase II preinitiation complex (PIC) production and the stimulation of transcription initiation are both facilitated by transcription factor II B (TFIIB), a general transcription factor.

Step 2:  TFIIB interaction with proteins could enhance the transcription of a gene

In the DNA, TFIIB binding with the proteins at the 3' end of genes and the DNA may cause a stem-loop formation. The promoter will be located adjacent to an RNA polymerase that has finished transcribing a gene, allowing transcription to start quickly.