Question

Question: The fusion of cancer cells with normal cells often suppresses the expression of the tumorigenic phenotype. Explain.

Short answer

Cancer is a disease in which a group of cells grows abnormally and divides indefinitely. A tumor is a swollen body area caused by abnormal tissue growth. Cancerous cells are distinct from healthy cells. Normal cells divide in an orderly fashion and are inhibited by contact.

Step-by-step solution

Cancer cells

The tumor is formed by unregulated cell proliferation and division, resulting in a huge tissue mass. They might be benign (non-cancerous) or cancerous (cancerous tumor) (Malignant).

Tumorigenic phenotype

Tumor cells' altered tumorigenicity has been thought to reflect their (nuclear) genetic and cellular abnormalities. Recent research has revealed that mitochondria may play a significant role in the mechanism by which cytoplasmic components contribute to the malignant phenotype of cancer.

Explanation for a given statement.

Tumor cells have the ability to merge with normal cells. A TN-hybrid is formed when a normal cell and a tumor cell fuse (tumor-normal hybrid). These hybrids are cancer-free.

The particular genes, which are tumor suppressor genes in normal cells, work to prevent tumor growth. These genes may trigger apoptosis by slowing aberrant cell division and repairing damage to the Deoxyribonucleic acid strand. The tumorigenic phenotype is suppressed as a result of this.