Question

In some proteins, the side-chain carboxylate carbon of an N-terminal glutamate residue reacts with the free amino group to form a pentagonal lactam, a cyclic structure containing ac=0 group. Draw the resulting pyroglutamate residue.

Short answer

The structure of pyroglutamate residue is –

Step-by-step solution

Concept Introduction

Pyroglutamic acid (PCA,oxyproline, pidolic acid) is a natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to create a lactam.

Structure of Pyroglutamate Residue

The structure is as follows –

Therefore, the structure is obtained.