Question

Is it possible for a native protein to be entirely irregular—that is, without α helices, β sheets, or other repetitive secondary structures?

Short answer

Yes, it is possible for a native protein to be entirely irregular.

Step-by-step solution

Introduction of native proteins.

Native proteins are those proteins which are in their folded or assembled form and are fully functional. They remain unaffected by denaturing agent namely chemical treatment, enzyme action, heat, etc.

Irregularity in native proteins.

Native proteins with low confirmational stability arre easily susceptible to denaturation.

This denaturation is caused by altering the balance of the weak non-bonding forces which maintain the native confirmation. Denaturation can occur by either of the following denaturants:

1. Heat,
2. pH variation,
3. Detergents, or
4. Chaotropic agents.