Chapter 7: Q20CP (page 217)
Why do the symptoms of an autoimmune disease often differ between individuals?
The symptoms of an autoimmune disease often differ between individuals due to their difference in locations and severity.
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Explain why the variation in VL and VH domains of immunoglobulins is largely confined to the hypervariable loops.
Is myosin a fibrous protein or a globular protein? Explain.
Explain why mutations can increase or decrease the oxygen affinity and cooperativity of hemoglobin. How can the body compensate for those changes?
An anemic individual, whose blood has only half the normal Hb content, may appear to be in good health. Yet a normal individual is incapacitated by exposure to sufficient carbon monoxide to occupy half of his/her heme sites (pCO of 1 torr for∼1 h; CO binds to Hb with 200-fold greater affinity than does O2). Explain.
In the variant hemoglobin C, glutamate at position 6 of the β chain has been replaced with lysine. (a) Would you expect this mutant hemoglobin to polymerize as hemoglobin S does? (b) Red blood cells containing hemoglobin C have a shorter lifespan than red blood cells containing normal hemoglobin. How might this affect a person’s resistance to malaria?
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