Chapter 7: Q18. (page 219)
Many fish produce a tetrameric IgM. If each H chain has a mass of 70 kD, each light chain has a mass of 25 kD, and each J chain has a mass of 15 kD, what is the approximate mass of the IgM molecule?
The approximate mass of the IgM molecule is 775 kD.
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Antibodies are well suited for recognizing extracellular substances from invading bacteria and viruses. However, the immune system must also be able to respond to intracellular infections. Explain why the immune system includes binding proteins that recognize F-actin.
The crocodile, which can remain under water without breathing for up to 1 h, drowns its air-breathing prey and then dines at its leisure. An adaptation that aids the crocodile in doing so is that it can utilize virtually 100% of the O2 in its blood, whereas humans, for example, can extract onlyโผ65% of the O2in their blood. Crocodile Hb does not bind BPG. However, crocodile deoxyHb preferentially binds HCO3โ. How does this help the crocodile obtain its dinner?
In the variant hemoglobin C, glutamate at position 6 of the ฮฒ chain has been replaced with lysine. (a) Would you expect this mutant hemoglobin to polymerize as hemoglobin S does? (b) Red blood cells containing hemoglobin C have a shorter lifespan than red blood cells containing normal hemoglobin. How might this affect a personโs resistance to malaria?
In hemoglobin Rainier, Tyr 145ฮฒ is replaced by Cys, which forms a disulfide bond with another Cys residue in the same subunit. This prevents the formation of ion pairs that normally stabilize the T state. How does hemoglobin Rainier differ from normal hemoglobin with respect to (a) oxygen affinity, (b) the Bohr effect, and (c) the Hill constant?
Describe how myoglobin and hemoglobin function in delivering O2 from the lungs to respiring tissues.
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