Question

Describe the production of dNTPs from their corresponding NDPs.

Short answer

The production of dNTP from NDP is as follows:

$$\begin{gathered} NDP\underset{ribonucleotidereductase}{\to }dNDP \\ dNDP+ATP\underset{kinase}{\to }dNTP+ADP \end{gathered}$$

Step-by-step solution

Nucleotides

The nucleotides are the components of the nucleic acids, including ribonucleic acid (RNA) and deoxyribonucleic acid (DNA).It contains sugar moiety, including ribose sugar and deoxyribose sugar, nitrogenous base, and the phosphate group.

Production of dNDP from NDP

The deoxyribonucleoside diphosphate (dNDP) is produced from the ribonucleoside diphosphate (NDP) by the ribonucleotide reductases.

$NDP\underset{ribonucleotidereductase}{\to }dNDP$

Production of dNTP from dNDP

The deoxyribonucleotide triphosphate (dNTP) can be produced by the phosphorylation of the dNDP, which is catalyzed by the kinase enzyme.

$dNDP+ATP\underset{kinase}{\to }dNTP+ADP$