Question

List all the enzymes of nucleotide biosynthesis that use glutamine as an amino group donor.

Short answer

Amidophosphoribosyl transferase, FGAM synthetase, GMP synthetase, carbamoyl phosphate synthetase II, and CTP synthetase are enzymes that use glutamine as an amino group donor.

Step-by-step solution

Definition of Concept

Glutamine: Glutamine is an amide-group amino acid. Amide groups contain amino groups that enzymes can transfer.

Step 2:List all the enzymes of nucleotide biosynthesis

The amino group is made up of three single bonds and has the atom N.

It is an ammonia derivative with one or more alkyl or aromatic groups replacing one or more H atoms.

amine has one hydrogen replaced by an organic group, has two hydrogens replaced, and has three.

Nucleotides with amino groups are: ${}^{\text{*}}\mid {\text{MP}}^{\text{*}}{\text{GMP*}}^{\text{*}}\text{UMP*CTP}$

Glutamine is used in steps 2 and 5 of the IMP synthesis process. The enzyme in step 2 is amidophosphoribosyltransferase, and the enzyme in step 5 is synthetase.

IMP is used to make GMP. GMP synthetase adds an amino group to the final step.

The enzyme carbamoyl phosphate synthetase II adds an amino group from glutamine in the first step of UMP synthesis.

CTP is made up of UTP, which is made up of UMP. UTP is given an amino group by CTP synthetase.