Question

List the starting materials and cofactors required for IMP biosynthesis.

Short answer

The starting material -D-ribose-5-phosphate, and eleven cofactors are used in the biosynthesis of inosine monophosphate (IMP).

Step-by-step solution

Starting materials required for the biosynthesis of inosine monophosphate (IMP).

The inosine monophosphate (IMP) is the purine derivative of the base hypoxanthine. The starting material of the inosine monophosphate (IMP) is -D-ribose-5-phosphate.

Cofactors.

The cofactors are non-protein compounds. They play the role of an enzyme as a catalyst and increase the reaction rate.

Cofactors required for the biosynthesis of inosine monophosphate (IMP).

1. Ribose phosphate pyrophosphokinase.
2. Amidophosphoribosyl transferase.
3. Glycinamide ribotide (GAR) synthetase.
4. Glycinamide ribotide (GAR) transformylase.
5. Formylglycinamidine ribotide (FGAM) synthetase.
6. 5-Aminoimidazole ribotide (AIR) synthetase.
7. 5-Aminoimidazole ribotide (AIR) carboxylase.
8. 5-Aminoimidazole-4-(N-succinylocarboxamide) ribotide (SAICAR) synthetase.
9. Adenylosuccinate lyase.
10. 5-Aminoimidazole-4-carboxamide ribotide (AICAR) transformylase.
11. Inosine monophosphate (IMP) cyclohydrolase.