Chapter 23: Q18P (page 829)
Describe how the fumarate produced by the purine nucleotide cycle could be catabolized to CO2.
Short Answer
The citric acid cycle can catabolize the fumarate generated by the purine nucleotide cycle to CO2.
Chapter 23: Q18P (page 829)
Describe how the fumarate produced by the purine nucleotide cycle could be catabolized to CO2.
The citric acid cycle can catabolize the fumarate generated by the purine nucleotide cycle to CO2.
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Get started for freeNormal cells die in a nutrient medium containing thymidine and methotrexate, whereas mutant cells defective in thymidylate synthase survive and grow. Explain.
Describe the reactions that convert IMP to ATP and GTP.
What is the function of the purine nucleotide cycle?
Rats are given cytidine that is14C-labeled at both its base and ribose components. Their DNA is then extracted and degraded with nucleases. Describe the labeling pattern of the recovered deoxycytidylate residues if deoxycytidylate production in the cell followed a pathway in which (a) intact CDP is reduced to dCDP, and (b) CDP is broken down to cytosine and ribose before reduction.
How are CTP and UTP derived from UMP?
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