Chapter 23: Q17P (page 829)
Is allopurinol a mechanism-based inhibitor of xanthine oxidase?
Allopurinol is a mechanism-based inhibitor of xanthine oxidase because its oxidation product irreversibly inhibits the enzyme.
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Describe how free purines are converted back to nucleotides.
Certain glutamine analogs irreversibly inactivate enzymes that bind glutamine. Identify the nucleotide biosynthetic intermediates that accumulate in the presence of those compounds.
6-Mercaptopurine (Box 23-2), after its conversion to the corresponding nucleotide through salvage reactions, is a potent competitive inhibitor of IMP in the pathways for AMP and GMP biosynthesis. It is therefore a clinically useful anticancer agent. The chemotherapeutic effectiveness of 6-mercaptopurine is enhanced when it is administered with allopurinol. Explain the mechanism of this enhancement.
Why is it important that muscle cells have low levels of glutamate dehydrogenase?
Why does it make metabolic sense for UTP to inhibit carbamoylphosphate synthetase II, whereas ATP activates the enzyme?
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