Chapter 24: Q11P (page 876)
How is the melting curve of duplex DNA affected by decreasing the ionic strength of the solution?
The Tm value of the melting curve of duplex DNA decreases as the ionic strength of the solution decreases.
Over 30 million students worldwide already upgrade their learning with Vaia!
All the tools & learning materials you need for study success - in one app.
Get started for free
Compounds known as peptide nucleic acids (PNAs) have been developed as nucleic acid-binding probes. A PNA molecule has a polypeptide-like backbone with purine and pyrimidine bases attached as side chains. Draw the PNA backbone resulting from amide bond formation between two molecules ofN-(2-aminoethyl)glycine.
The asterisk in the structure shown in Problem 31 indicates the site where the base is attached via a two-carbon linker. Compare the overall backbone length for a PNA and a DNA molecule and explain why the two molecules can form base-paired duplexes.
Infection with the influenza virus interferes with the normal expression of genes in the host cell. The viral protein M1 binds to histones electrostatically. (a) Would increasing the salt concentration promote or weaken M1–histone binding? (b) Would decreasing the pH promote or weaken M1–histone binding?
What is the probability that the palindromic symmetry of the trp repressor target DNA sequence (Section 24-4B) is merely accidental?
Calculate the contour length for the gene in in Problem 3 if it assumed an A-DNA conformation.
What do you think about this solution?
We value your feedback to improve our textbook solutions.
