Membrane transport proteins cross the lipid bilayer with sections visible on both sides. Some transmembrane proteins do not reach the hydrophobic core of the lipid bilayer. Instead, noncovalent interactions with other membrane proteins attach them to the proteins on both sides of the membrane.
Many of these transmembrane proteins are released from the membrane by procedures, such as exposure to solutions of extremely high or low ionic strength, or extreme pH, which interfere with protein-protein interaction. However, some proteins are held in the lipid bilayer of lipid groups by unusually tight binding that cannot be released in these ways, preventing the movement of water and ion molecules across the membrane.