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Why would overexpression of an MDR transporter in a cancer cell make cancer more difficult to treat?

Short Answer

Expert verified

The MDR transporter removes the anti-cancer drugs from the cell, thus preventing the treatment of cancer cells.

Step by step solution

01

Introduction

The ABC transporter family includes the multidrug resistance (MDR) transporter. This transporter is responsible for removing a range of amphiphilic compounds from the cell, including medicines.

02

MDR transporter in cancer cells

The capacity of cancer cells to excreteanti-cancer medicines would be increased if the MDR transporter was overexpressed. Anti-cancer drug molecules are pumped out of the cell via theMDR transporter.

Overexpression of theP-glycoprotein membrane protein,an MDR protein, explains why anti-cancer medicines fail to kill cancer cells. In order to reduce the quantity of P- glycoprotein, larger medication concentrations are required.

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