Chapter 22: Q7CP (page 781)
Without looking at the text, draw diagrams of these two metabolic cycles.
Chapter 22: Q7CP (page 781)
Without looking at the text, draw diagrams of these two metabolic cycles.
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Get started for freeHigh concentrations of free fatty acids in the blood are known to cause insulin resistance in muscle, but only after 5 hours. This suggests that a metabolite of the fatty acids may be responsible for this phenomenon. It is also known that an isoform of protein kinase C is activated during the process and that high concentrations of free fatty acids result in intramuscular accumulation of triacylglycerols. With this information, review the mechanism of activation of PKC and the pathway of triacylglycerol biosynthesis and suggest a metabolite that may be responsible for PKC activation.
Explain why a common diagnostic test for diabetes involves orally administering a glucose solution to an individual and then measuring the concentration of blood glucose two hours later.
How does thermogenesis help prevent obesity?
Individuals with a deficiency of medium chain acyl-CoA dehydrogenase (MCAD) tend to develop nonketotic hypoglycemia. Explain why this defect makes them unable to undertake (a) ketogenesis and (b) gluconeogenesis.
Compare the roles of leptin, ghrelin, insulin, and PYY in controlling appetite.
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