Question

In experiments to test the appetite-suppressing effects of $\mathit{P}\mathit{Y}{\mathit{Y}}_{\mathbf{3}\mathbf{-}\mathbf{36}}$why must the hormone be administered intravenously rather than orally?

Short answer

Because of its short breakdown period, the hormone $PY{Y}_{3-36}$should be given intravenously rather than orally.

Step-by-step solution

PYY3-36

$PY{Y}_{3-36}$is a peptide (NPY) hormone, which reduces hunger. The gastrointestinal tract secretes this peptide hormone. It works by reducing the secretion of the neuropeptide Y.

Effect of  PYY3-36

$PY{Y}_{3-36}$is a short-term appetite regulator.$PY{Y}_{3-36}$ has a quick degradation period since it is a short-term regulator hormone. Anything taken orally takes longer to have an effect, whereas anything taken intravenously has a faster effect. Because orally injected substances must first pass through the digestive tract before they can be absorbed into blood vessels, this is the case. If $PY{Y}_{3-36}$is injected orally, it will not have enough time to affect the organism because it is digested quickly by the body.