Chapter 9: Q33P (page 291)
Question: Predict the effect of a mutation in signal peptidase that narrows its specificity so that it cleaves only between two Leu residues.
Answer
Theproteins fold abnormally and function abnormally.
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What products are obtained when 1-palmitoyl-2-oleoyl-3-phosphatidylserine is hydrolyzed by (a) phospholipase A1; (b) phospholipase A2; (c) phospholipase C; (d) phospholipase D?
Question: Archae bacteria and Eubacteria produce different types of membrane lipids. How does the archaeal lipid shown here differ from phosphatidyl-glycerol?
What are the two types of secondary structures that occur in transmembrane proteins?
Why are biological membranes asymmetrical?
Macropinocytosis is a variation of endocytosis in which cells take up large amounts of extracellular fluid, which accumulates in intracellular vesicles. The drug vacquinol stimulates macropinocytosis in the cells that form a glioblastoma, a type of tumor. Propose an explanation why excessive macropinocytosis would lead to cell death.
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