Question

Question: In some autoimmune diseases, an individual develops antibodies that recognize cell constituents such as DNA and phospholipids. Some of the antibodies react with both DNA and phospholipids. What is the structural basis for this cross-reactivity?

Short answer

Answer

Both DNA and the phospholipidshave exposed phosphate groups which are recognized by the antibodies

Step-by-step solution

Anti-Immune system

When a person's immune system assaults their own body, this is called an autoimmune condition. Around 80 distinct autoimmune illnesses exist, ranging in severity from moderate to severe, depending on which biological system is attacked and to what extent.Although there is no treatment for autoimmune illnesses, the symptoms may usually be controlled.

Structural basis for cross-reactivity

Both DNA and Phospholipidshave exposed phosphate groups that are recognized by antibodies.

Thus, DNA and Phospholipids has exposed the phosphate group.