Question

How does cytochrome P450 participate in drug metabolism?

Short answer

Cytochrome P450 participates in the drug metabolism through the process of enzyme metabolism which results in clinically important drug-drug interactions that produce side effects.

Step-by-step solution

Drug metabolism

The chemical change of the drug through a biological system to facilitate its excretion by increasing its hydrophilicity is known as drug metabolism. There are two stages of drug metabolism: Phase 1 contains oxidative processes such as those carried out by cytochrome P450s, as well as reduction and hydrolysis.

Cytochrome P450 in drug metabolism

Drug metabolism is aided by Cytochrome P450. The medications in the body can readily activate and inhibit this cytochrome P450. Drug-drug interactionsmay occur as a result. Unexpected adverse responses or treatment failures may result from these drug-drug interactions.

Role of cytochrome P450 in drug metabolism

Many drugs need the use of cytochrome P450 enzymesfor their metabolism. Drugs can inhibit or promote cytochrome P450 enzymes, resulting in clinically important drug-drug interactions that can produce unforeseen side effects or treatment failures. The cytochrome P450 enzymes are frequently involved in interactions with warfarin, antidepressants, antiepileptic medications, and statins.