Question

Design a chloromethylketone inhibitor of elastase.

Short answer

Tosyl-L-alanine chloromethylkeyone

Step-by-step solution

Inhibitor of digestive enzyme

Inhibitors of digestive enzymes inhibit the functional enzymes that switch off the functionality and activity of different digestive enzymes; for example, they inhibit trypsin and elastase.

Chloromethyl ketone inhibitor

One of the inhibitors of elastase is chloromethyl ketone inhibitor because it is a strong alkylating agent; it reacts only with His 57, thereby inactivating the enzyme elastase, which is designed as follows:

Tosyl-L-alanine chloromethylkeyone:Chloromethyl ketone inhibitor