Question

Two approaches for correcting single-gene defects are gene therapy such as is discussed in Section_{$\mathbf{\text{3 - 5D}}$}and the_{$\mathbf{\text{CRISPR - Cas9}}$}system. Explain why the_{$\mathbf{\text{CRISPR - Cas9}}$}approach can potentially provide more complete restoration of normal tissue function than gene therapy.

Short answer

The CRISPR-Cas 9 approach can be used in embroys to delete the genes for malfunctioned proteins. It uses a targeted gene insertion approach. So, it can provide a more complete restoration of normal tissue function.

Step-by-step solution

Define gene therapy

The process of modifying the genetic makeup of the cell that can produce a therapeutic effect to treat some disorders is known as gene therapy.

CRISPR - Cas9 approach provides more complete restoration of normal tissue function than gene therapy.

$\text{CRISPR - Cas9}$, or clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9, is a genome editing process that occurs naturally in prokaryotes. When compared to gene therapy, this gene system is simpler but more specific. In comparison to gene therapy, which requires the protein-DNA interface to be altered,$\text{CRISPR - Cas9}$simply need three component$\text{(Cas9, crRNA, and trRNA)}$to begin genome editing.

CRISPR-Cas 9 enables the insertion of a targeted gene that is superior in restoring normal protein function. It can also be used in embroys to delete the genes that can produce damaged protein.