Chapter 25: 3cp (page 882)
Why must DNA be replicated semi discontinuously?
DNA replication: - The process of copying the DNA is called DNA replication.
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A certain mutant DNA polymerase is error-prone, tending to incorporate C opposite a template A. When such a DNA polymerase replicates a segment of DNA containing an A · T base pair, what will be the DNA composition in the daughter cells after (a) one and (b) two rounds of cell division? Assume that DNA repair does not occur.
Certain sites in the E. coli chromosome are known as hot spots because they have unusually high rates of point mutations. Many of these sites contain a 5-methylcytosine residue. Explain the existence of such hot spots
In some experimental systems, a newly synthesized RNA primer is transferred from primase to the clamp or clamp loader rather than directly to DNA polymerase. Explain why this would maximize the efficiency of DNA replication
Explain why base excision repair, nucleotide excision repair, and mismatch repair—which all require nucleases to excise damaged DNA—require DNA ligase.
Yeast and some other organisms produce proteins that closely resemble -alkylguanine–DNA alkyltransferase but lack a Cys at the active site. (a) Explain why these proteins cannot remove an alkyl group attached to guanine. (b) These proteins do protect cells against DNA alkylation damage. In which type of repair process are these proteins most likely to participate?
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