Question

Which steps of the citric acid cycle regulate flux through the cycle?

Short answer

Flux is regulated by Isocitrate dehydrogenase, $\alpha$-ketoglutarate dehydrogenase, ATP, NADH, and the substrates.

Step-by-step solution

Define the Citric acid cycle

The tricarboxylic acid cycle, commonly known as the Krebs cycle, is a sequence of events that release stored energy by oxidizing acetyl CoA, which is produced from carbs, proteins, and fats.

Maintenance of flux in citric acid cycle

The continuous flow or occurrence of the citric acid cycle without any obstruction is referred to as the rate of flux. The following are the most important factors in maintaining the citric acid cycle's flux:

• Isocitrate dehydrogenase, is an enzyme that catalyzes the conversion of isocitrate to a-ketoglutarate and is allosterically activated by adenosine diphosphate (ADP).
• $\alpha$-ketoglutarate dehydrogenase is an enzyme that catalyzes the conversion of $\alpha$-ketoglutarate to succinyl CoA.
• Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide concentrations (NADH).
• The availability of the substrate.