Chapter 17: Q10CP (page 579)
How much ATP can be generated from glucose when the citric acid cycle is operating?
The net ATP production is 24 ATP.
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Question: Although animals cannot synthesize glucose from acetyl-CoA, if a rat is fed 14C-labeled acetate, some of the label appears in glycogen extracted from its muscles. Explain.
What is the ratio of [isocitrate] to [citrate] under cellular conditions at 37°C?
Photosynthetic organisms use elaborate machinery to incorporate carbon (as CO2) into glyceraldehyde-3-phosphate, which is used to synthesize glucose for later metabolism. However, one carbon is lost following glycolysis when the three-carbon pyruvate is converted to acetyl-CoA. The bacterial enzyme pyruvate-formate lyase (also known as formate C-acetyltransferase) catalyzes the reaction
How does this reaction help the cell avoid losing carbon?
List four possible metabolic fates for pyruvate in a mammalian cell. Indicate the type of reaction that occurs. What additional reaction occurs in yeast?
Theproduced in one round of the citric acid cycle does not originate in the acetyl carbons that entered that round. If acetyl-CoA is labeled withat its carbonyl carbon, how many rounds of the cycle are required beforeis released?
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