Chapter 13: Q18P (page 440)
Diacylglycerol is a substrate for the enzyme diacylglycerol kinase. What is the product of this reaction?
Diacylglycerol kinase phosphorylates diacylglycerol, removing it from the phosphoinositide pathway.
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Summarize the steps of signal transduction from a GPCR to phosphorylation of targetproteins by PKA.
Would the following alterations to Src be oncogenic? Explain.
(a) The deletion or inactivation of the SH3 domain.
(b) The mutation of Tyr 416 to Phe.
Describe how PKC activity requiresmembrane components.
The diagnosis of some lymphomas (blood cell cancers) includes cytogenetic analysis, which involves examining a patient’s cells for chromosomal
abnormalities. Chromosomes are visible by light microscopy only during cell division. Cells removed from a patient’s bone marrow may be treated with phorbol myristate acetate (PMA) prior to microscopic examination. What is the purpose of the PMA?
What biochemical changes are required to convert tyrosine to (a) norepinephrine and (b) epinephrine?
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