Chapter 7: Problem 3
Describe the cytological observation that suggests that crossing over occurs during the first meiotic prophase.
Chapter 7: Problem 3
Describe the cytological observation that suggests that crossing over occurs during the first meiotic prophase.
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Get started for freeWhy is a 50 percent recovery of single-crossover products the upper limit, even when crossing over always occurs between two linked genes?
Explain why restriction fragment length polymorphisms and microsatellites are important landmarks for mapping purposes.
Colored aleurone in the kernels of corn is due to the dominant allele \(R\). The recessive allele \(r,\) when homozygous, produces colorless aleurone. The plant color (not kernel color) is controlled by another gene with two alleles, \(Y\) and \(y\). The dominant \(Y\) allele results in green color, whereas the homozygous presence of the recessive \(y\) allele causes the plant to appear yellow. In a testross between a plant of unknown genotype and phenotype and a plant that is homozygous recessive for both traits, the following progeny were obtained: colored, green 88 colored, yellow 12 colorless, green 8 colorless, yellow 92 Explain how these results were obtained by determining the exact genotype and phenotype of the unknown plant, including the precise association of the two genes on the homologs (i.e., the arrangement).
In this chapter, we focused on linkage, chromosomal mapping, and many associated phenomena. In the process, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, what answers would you propose to the following fundamental questions? (a) How was it established experimentally that the frequency of recombination (crossing over) between two genes is related to the distance between them along the chromosome? (b) How do we know that specific genes are linked on a single chromosome, in contrast to being located on separate chromosomes? (c) How do we know that crossing over results from a physical exchange between chromatids? (d) How do we know that sister chromatids undergo recombination during mitosis?
Three loci, mitochondrial malate dehydrogenase that forms \(a\) and \(b(M D H a, M D H b),\) glucouronidase that forms 1 and \(2(G U S 1\) \(G U S 2\) ), and a histone gene that forms \(+\) and \(-(H+, H-),\) are located on chromosome \(\\# 7\) in humans. Assume that the \(M D H\) locus is at position \(35, G U S\) at position \(45,\) and \(H\) at position 75 A female whose mother was homozygous for \(M D H a, G U S 2,\) and \(H+\) and whose father was homozygous for \(M D H b, G U S 1,\) and \(H-\) produces a sample of 1000 egg cells. Give the genotypes and expected numbers of the various types of cells she would produce. Assume no chromosomal interference.
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