In chickens, a key gene involved in sex determination has
recently been identified. Called \(D M R T 1\), it is located on the \(Z\)
chromosome and is absent on the W chromosome. Like SRY in
humans, it is male determining. Unlike \(S R Y\) in humans, however, female
chickens (ZW) have a single copy while males (ZZ) have two copies of the gene.
Nevertheless, it is transcribed only in the developing testis. Working in the
laboratory of Andrew sinclair (a co-discoverer of the human SRY gene), Craig
Smith and colleagues were able to "knock down" expression of \(D M R T 1\) in
\(\mathrm{ZZ}\) embryos using RNA interference techniques (see Chapter 15 ). In
such cases, the developing gonads look more like ovaries than testes [Nature
461: 267 (2009)]. What
conclusions can you draw about the role that the DMRTI gene plays in chickens
in contrast to the role the SRY gene plays in humans?