Chapter 5: Problem 22
What does the apparent need for dosage compensation mechanisms suggest about the expression of genetic information in normal diploid individuals?
Chapter 5: Problem 22
What does the apparent need for dosage compensation mechanisms suggest about the expression of genetic information in normal diploid individuals?
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Get started for freeHow do mammals, including humans, solve the "dosage prob- lem" caused by the presence of an \(\mathrm{X}\) and \(\mathrm{Y}\) chromosome in one sex and two X chromosomes in the other sex?
What is a Barr body, and where is it found in a cell?
In Drosophila, an individual female fly was observed to be of the \(\mathrm{XXY}\) chromosome complement (normal autosomal complement) and to have white eyes as contrasted with the normal red eye color of wild type. The female's father had red eyes, and the mother had white eyes. Knowing that white eyes are X-linked and recessive, present an explanation for the genetic and chromosomal constitution of the XXY, whiteeyed individual. It is important that you state in which parent and at what stage the chromosomal event occurred that caused the genetic and cytogenetic abnormality.
In this chapter, we have focused on sex differentiation, sex chro- mosomes, and genetic mechanisms involved in sex determination. At the same time, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, you should answer the following fundamental questions: (a) How do we know that in humans the X chromosomes play no role in sex determination, while the Y chromosome causes maleness and its absence causes femaleness? (b) How did we originally (in the late 1940 s) analyze the sex ratio at conception in humans, and how has our approach to studying this issue changed in \(2015 ?\) (c) How do we know that \(X\) chromosomal inactivation of either the paternal or maternal homolog is a random event during early development in mammalian females? (d) How do we know that Drosophila utilizes a different sexdetermination mechanism than mammals, even though it has the same sex-chromosome compositions in males and females?
Describe how nondisjunction in human female gametes can give rise to Klinefelter and Turner syndrome offspring following fertilization by a normal male gamete.
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